Influence of variation of the serum creatinine on outcomes of patient with acute kidney injury
DOI:
https://doi.org/10.15253/2175-6783.20181933348Keywords:
Acute Kidney Injury; Creatinine; Mortality.1Universidade de Brasília. Brasília, DF, Brasil.Autor correspondente: Tayse Tâmara da Paixão DuarteFaculdade de Ceilândia – Universidade de Brasília.Departamento de Enfermagem.Centro Metropolitano, conjunto A, lote 01. CEP: 72220-900. Brasília, DF, Brasil. E-mail: taysepaixao@unb.brAbstract
Objective: to identify the influence of variations on serum creatinine on outcomes of patients with acute kidney failure. Methods: observational and prospective study. Eighty-five patients which evolved with renal impairment composed the sample. The data was extracted from medical records and reported in a questionnaire created previously. It was considered values p≤0.05 as significant. Results: most of patients were male gender (51.8%) and elder (66±14 years). The reduction of kidney function occurred in different graduation, considering that 35.3% evolved with risk to kidney injury (stage 1) and lower percentage (14.1%) was more severely affected (stage 2 and 3), respectively. During follow-up, the clearance creatinine progressively increased showing recovery of kidney function. Patients with renal injury or failure (stage 2 or 3) evolved more frequently to death (p=0,027). Conclusion: variations on serum creatinine may exacerbate the patient outcomes over hospitalization period.
References
Petronijevic Z, Selim G, Petkovska L, Georgievska-Ismail L, Spasovski G, Tozija L. The effect of treatment on short-term outcomes in elderly patients with acute kidney injury. Open Access Maced J Med Sci. 2017; 5(5):635-40. doi: http://dx.doi.org/10.3889/oamjms.2017.148
Rewa O, Basgshaw SM. Acute kidney injury-epidemiology, outcomes and economics. Nat Rev Nephrol. 2014; 10(4):193-207. doi: http://dx.doi.org/10.1038/nrneph.2013.282
Kidney Disease Improving Global Outcomes (KDIGO). Working Group. Definition and classification of acute kidney injury. Kidney Int Suppl [Internet]. 2012 [cited July 02, 2018]; 2:19-36. Available from: http://www.kdigo.org/clinical_practice_guidelines/pdf/KDIGO%20AKI%20Guideline.pdf
Soares LO, Brune MFSS. A avaliação da função renal em adultos por meio da taxa de filtração glomerular e microalbuminúrica. Rev Bras Pesq Saúde. 2017; 19(3):62-8. doi: https://doi.org/10.21722/rbps.v19i3.19566
Koeze J, Keus F, Dieperink W, van der Horst IC, Zijlstra JG, Van Meurs M. Incidence, timing and outcome of AKI in critically ill patients varies with the definition used and the addition of urine output criteria. BMC Nephrol. 2017; 18(1):70. doi: http://dx.doi.org/10.1186/s12882-017-0487-8
Talib S, Sharif F, Manzoor S, Yaqub S, Kashif W. Charlson comorbidity index for prediction of outcome of acute kidney injury in critically ill patients. Iran J Kidney Dis [Internet]. 2017 [cited July 04, 2018];11(2):115-23. Available from: http://www.ijkd.org/index.php/ijkd/article/view/2855/907
Siew ED, Davenport A. The growth of acute kidney injury: a rising tide or just closer attention to detail? Kidney Int. 2015; 87(1): 46-61. doi: http://dx.doi.org/10.1038/ki.2014.293
Lysak N, Bihorac A, Hobson C. Mortali-ty and cost of acute and chronic kidney di-seaseaftercardiac surgery. Curr Opin Anaesthsi-ol. 2017; 30(1):113-7. doi: http://dx.doi.org/10.1097/ACO.0000000000000422
Pickering JW, Endre ZH. Back-calculating baseline creatinine with MDRD misclassifies acute kidney Injury in the Intensive Care Unit. Clin J Am Soc Nephrol. 2010; 5(7):1165-73. doi: http://dx.doi.org/10.2215/CJN.08531109
Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbi- dity in longitudinal studies: development and va- lidation. J Chronic Dis [Internet]. 1987 [cited July 06, 2018]; 40(5):373-83. Available from: http://www.aqc.ch/download/HSM_Suppl_8_charlson.pdf
Schiffl H. Prevention of severe acute kidney injury by implementation of care bundles: Some progress but still a lot of work ahead. Saudi J Kidney Dis Transpl. 2018; 29(3):513-7. doi: http://dx.doi.org/10.4103/1319-2442.235195
Hoste EA, Bagshaw SM, Bellomo R, Cely CM, Col-man R, Cruz DN, et al. Epidemiology of acute kid-ney injury in critically ill patients: the multina-tional AKI-EPI study. Intensive Care Med. 2015; 41(8):1411-23. doi: http://dx.doi.org/10.1007/s00134-015-3934-7
Hamzić-Mehmedbašić A, Rašić S, Balavac M, Rebić D, Delić-Šarac M, Durak-Nalbantić A. Prognostic indicators of adverse renal outcome and death in acute kidney injury hospital survivors. J Renal InjPrev [Internet].2016 [cited 2018 July 10]; 5(2):61-8. doi: http://dx.doi.org/10.15171/jrip.2016.14
Petronijevic Z, Selim G, Petkovska L, Georgievska-Ismail L, Spasovski G, Tozija L. The Effect of Treatment on Short-Term Outcomes in Elderly Patients with Acute Kidney Injury. Open Access Maced J Med Sci. 2017; 5(5):635-40. doi: http://dx.doi.org/10.3889/oamjms.2017.148
Brown JR, Rezaee ME, Marshall EJ, Matheny ME. Hospital mortality in the United States following acute kidney injury. Biomed Res Int. 2016; 2016:4278579. doi: http://dx.doi.org/10.1155/2016/4278579
Garasto S, Fusco S, Corica F, Rosignuolo, Marino A, Montesanto, et al. Estimating glomerular filtration rate in older people. Biomed Res Int. 2014; 2014:916542. doi: http://dx.doi.org/10.1155/2014/916542
Rigonatto MCL, Magro MCS. Risk for acute kidney injury in primary health care. Rev Bras Enferm. 2018; 71(1):20-5. doi: http://dx.doi.org/10.1590/0034-7167-2016-0551
Moura SLF, Duarte TTP, Magro MCS. Severity and outcome of patientes with acute. Rev Enferm UFPE on line [Internet]. 2017 [cited July 13, 2018]; 11(11):4319-25. Available from: https://periodicos.ufpe.br/revistas/revistaenfermagem/article/viewFile/23537/24677
Domingueti CP, Fóscolo RB, Dusse LMS, Reis JS, Carvalho MDG, Gomes KB, et al. Association of different biomarkers of renal function with D-di-mer levels in patients with type 1 diabetes melli-tus (renal biomarkers and D-dimer in diabetes). Arch Endocrinol Metab. 2018; 62(1):27-33. doi: http://dx.doi.org/10.20945/2359-3997000000003
Muthuppalaniappan VM, Yaqoob MM. Ethnic/race diversity and diabetic kidney disease. J Clin Med. 2015; 4(8):1561-5. doi: http://dx.doi.org/10.3390/jcm4081561
