Use of post-exposure prophylaxis for HIV in young people: an integrative review
DOI:
https://doi.org/10.15253/2175-6783.20222378152Keywords:
Health Education; HIV; HIV Infections; Post-Exposure Prophylaxis; Technology.Abstract
Objective: to identify the use of post-exposure prophylaxis for HIV in young people in the context of sexual risk behavior. Methods: this is an integrative review, with search in LILACS, MEDLINE, CINAHL, SCOPUS, SciELO and COCHRANE, using the main descriptors: HIV, HIV Infections, Health Education, Technology and Post-Exposure Prophylaxis related through the Boolean operators AND and OR. Results: the final sample included 16 studies, mostly implemented with men who have sex with men. The articles were classified and analyzed from the categories: knowledge assessment; barriers/challenges to adherence to post-exposure prophylaxis; population using post-exposure prophylaxis; and educational technologies. Conclusion: non-adherence was related to the ignorance of basic information such as the indication of post-exposure prophylaxis, place of delivery, dosage, and side effects. Contributions to practice: synthesis of knowledge about the use of post-exposure prophylaxis by young people. In addition to increasing research on young people in the context of risky sexual behavior, especially in the nursing field, it subsidizes the development of health education strategies.
References
Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Boletim Epidemiológico de HIV e Aids [Internet]. 2020 [cited Jan. 10, 2022]. Available from: http://www.aids.gov.br/pt-br/pub/2020/boletim-epidemiologico-hivaids-2020
United Nations International Children’s Emergency Fund - UNICEF. Adolescent HIV prevention [Internet]. 2021 [cited Apr. 11, 2022]. Available from: https://data.unicef.org/topic/hivaids/adolescents-young-people/
Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Prevenção combinada do HIV: bases conceituais para profissionais, trabalhadores (as) e gestores (as) de saúde [Internet]. 2017 [cited Apr. 11, 2022]. Available from: http://www.aids.gov.br/pt-br/pub/2017/prevencao-combinada-do-hiv-bases-conceituais-para-profissionais-trabalhadoresas-e-gestores
Lima MS, Raniere JC, Paes CJO, Gonçalves LHT, Cunha CLF, Ferreira GRON, et al. The association between knowledge about HIV and risk factors in young Amazon people. Rev Bras Enferm. 2020;73(5):e20190453. doi: https://doi.org/10.1590/0034-7167-2019-0453
Ministério da Saúde (BR). Departamento de vigilância, controle e prevenção de infecções. Protocolo clínico e diretrizes terapêuticas para manejo da infecção pelo HIV em adultos. [Internet]. 2018 [cited Apr. 11, 2022]. Available from: http://www.aids.gov.br/pt-br/pub/2013/protocolo-clinico-e-diretrizes-terapeuticas-para-manejo-da-infeccao-pelo-hiv-em-adultos
Mendes KDS, Silveira RCDCP, Galvão CM. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto Contexto Enferm. 2008;17(4):758-64. doi: http://doi.org/10.1590/S0104-07072008000400018
World Health Organization. Adolescent health: Adolescent health in the South-East Asia Region [Internet]. 2019 [cited Apr. 11, 2022]. Available from: https://www.who.int/southeastasia/health-topics/adolescent-health
Melnyk BM, Fineout-Overholt E, Stillwell S, Williamson K. Evidence-based practice: step by step: the seven steps of evidence-based practice. Am J Nurs. 2010;110(1):51-3. doi: https://dx.doi.org/10.1097/01.NAJ.0000366056.06605.d2
Tumarkin E, Heendeniya A, Murphy P, Placido T, Tan DHS, Bogoch II. Brief report: HIV Postexposure Prophylaxis-in-Pocket (“PIP”) for individuals with low-frequency, high-risk HIV exposures. J Acquir Immune Defic Syndr. 2018;78(1):20-2. doi: http://doi.org/10.1097/QAI.0000000000001639
Hou J, Wu Y, Xie L, Meng S, Fu R, Zheng H, et al. Post-exposure prophylaxis: an underutilized biomedical HIV prevention method among gay, bisexual and other men who have sex with men in China. AIDS Care. 2020;32(12):1573-80. doi: https://dx.doi.org/10.1080/09540121.2020.1742864
Koblin BA, Usher D, Nandi V, Tieu HV, Bravo E, Lucy D, et al. Post-exposure prophylaxis awareness, knowledge, access and use among three populations in New York City, 2016–17. AIDS Behav. 2018;22(8):2718-32. doi: https://dx.doi.org/10.1007/s10461-018-2175-5
Grangeiro A, Nascimento MMP, Zucchi EM, Ferraz D, Escuder MM, Arruda E, et al. Nonoccupational post-exposure prophylaxis for HIV after sexual intercourse among women in Brazil: risk profiles and predictors of loss to follow-up. Medicine (Baltimore). 2019;98(39):e17071. doi: https://doi.org/10.1097/MD.0000000000017071
Palich R, Martin-Blondel G, Cuzin L, Le Talec JY, Boyer P, Massip P, et al. Experiences of HIV postexposure prophylaxis (PEP) among highly exposed men who have sex with men (MSM). Sex Transm Infect. 2017;93(7):493-8. doi: https://dx.doi.org/10.1136/sextrans-2016-052901
Körner H, Hendry O, Kippax S. Safe sex after post-exposure prophylaxis for HIV: intentions, challenges and ambivalences in narratives of gay men. AIDS Care. 2006;18(8):879-87. doi: https://doi.org/10.1080/09540120500307909
Goedel WC, Hagen D, Halkitis PN, Greene RE, Griffin-Tomas M, Brooks FA, et al. Post-exposure prophylaxis awareness and use among men who have sex with men in London who use geosocial-networking smartphone applications. AIDS Care. 2017;29(5):579-86. doi: https://doi.org/10.1080/09540121.2016.1259455
Hugo JM, Stall RD, Rebe K, Egan JE, Jobson G, Swardt G, et al. Knowledge, attitudes and beliefs regarding post exposure prophylaxis among South African men who have sex with men. AIDS Behav. 2016;20(Suppl 3):350-6. doi: https://doi.org/10.1007/s10461-016-1520-9
Shahmoradi L, Safadari R, Jimma W. Knowledge management implementation and the tools utilized in healthcare for evidence-based decision making: a systematic review. Ethiop J Health Sci. 2017;27(5):541-58. doi: http://doi.org/10.4314/ejhs.v27i5.13
Fernández‐Balbuena S, Belza MJ, Castilla J, Hoyos J, Rosales‐Statkus ME, Sánchez R, et al. Awareness and use of nonoccupational HIV post‐exposure prophylaxis among people receiving rapid HIV testing in Spain. HIV Med. 2013;14(4):252-7. doi: http://doi.org/10.1111/j.1468-1293.2012.01056.x
Isano S, Wong R, Logan J, El-Halabi, S, El-Khatib Z. Barriers to post exposure prophylaxis use among men who have sex with men in sub-Saharan Africa: an online cross-sectional survey. Prev Med Rep. 2020;19(1):e101100. doi: https://doi.org/10.1016/j.pmedr.2020.101100
Gupta N, Schmidt H, Buisker T, Dufour MSK, Goldenson J, Myers J, et al. After the fact: a brief educational program on HIV postexposure prophylaxis for female detainees in a local jail. J Correct Health Care. 2015;21(2):140-51. doi: https://doi.org/10.1177/1078345815572335
Oldenburg CE, Bärnighausen T, Harling G, Mimiaga MJ, Mayer KH. Adherence to post-exposure prophylaxis for non-forcible sexual exposure to HIV: a systematic review and meta-analysis. AIDS Behav. 2014;18(2):217-25. doi: https://doi.org/10.1007/s10461-013-0567-0
Dodds C. Positive benefits: preventive impact of post-exposure prophylaxis awareness among those with diagnosed HIV. Sex Transm Infect. 2008;84(2):92-3. doi: https://doi.org/10.1136/sti.2007.026211
Kalichman S. Post-exposure prophylaxis for HIV infection in gay and bisexual men: implications for the future of HIV prevention. Am J Prev Med. 1998;15(2):120-7. doi: https://doi.org/10.1016/S0749-3797(98)00037-3
Lewis CF, Lekas HM, Rivera A, Williams SZ, Crawford ND, Pérez-Figueroa RE, et al. Pharmacy PEP access intervention among persons who use drugs in New York city: iPEPcare study-rethinking biomedical HIV prevention strategies. AIDS Behav. 2020;24(7):2101-11. doi: https://doi.org/10.1007/s10461-019-02775-3
Moraes DCDA, Oliveira RCD, Prado AVAD, Cabral JDR, Corrêa CA, Albuquerque MMBD. Knowledge of people living with HIV/Aids about antiretroviral therapy Enferm Glob. 2017;17(49):96-141. doi: https://dx.doi.org/10.6018/eglobal.17.1.274001
Tshering K, Wangchuk K, Letho Z. Assessment of knowledge, attitude and practice of post exposure prophylaxis for HIV among nurses at Jigme Dorji Wanghuck National Referral Hospital, Bhutan. PLoS One. 2020;15(8):e0238069. doi: https://doi.org/10.1371/journal.pone.0238069
Charpentier N, Quatremère G, Mabire X, Roduit S, Laguette V, Spittler D, et al. Freins et leviers de la prise en charge du traitement post-exposition au VIH. Santé Publique [Internet]. 2016 [cited Jan. 13, 2022];28(6):791-9. Available from: https://www.cairn.info/revue-sante-publique-2016-6-page-791.htm
Hakim AJ, Callahan T, Benech I, Patel M, Adler M, Modi S, et al. Addressing vulnerable population needs in the last mile to the elimination of mother to child transmission of HIV: (Re) claiming the HIV response for female sex workers and their children. BMC Public Health. 2020;20:1015. doi: https://doi.org/10.1186/s12889-020-09114-5
