General instructions and Ethical aspects

Authorship: The concept of authorship is based on the substantial contribution of each of the persons listed as authors. Authorship criteria should be based on the deliberations of the International Committee of Medical Journal Editors (, which recommends that authorship be based on the following criteria: 1. Conception or design of the work, or the acquisition, analysis, or interpretation of data; 2. Drafting the manuscript or revising it critically for important intellectual content; 3. Final approval of the version to be published; and 4. Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. These four conditions must be fully met. All those designated as authors must meet the authorship criteria.

The maximum number of authors is seven. The inclusion of co-authors whose contribution does not meet the above criteria is not justified. People who provided technical or general support can be mentioned in the Acknowledgments section. All authors must inform their ORCID registration number (

Conflict of interest: All authors and reviewers must disclose any conflict of interest that may have arisen during the development of the study.

Funding: Declare the institutional or private sources of funding for carrying out the study. For those without financial resources, inform that the research received no funding. In the case of financial support from an institution, inform the grant number.

Copyright: In case of approval of the manuscript, all material published will become Rev Rene's property, and the journal will become the holder of the authors' rights. The authors must forward a Statement of Responsibility and Copyright Transfer, signed by all co-authors (download).

Ethical aspects

This journal follows the recommendations of the Committee on Publication Ethics (COPE) and the Code of Conduct and Best Practice Guidelines for Journal Editors. The journal adopts the Uniform Requirements for manuscripts submitted to biomedical journals (Vancouver style).

The ethical precepts of research involving human beings or animal experimentation must be respected. The publication of manuscripts reporting research results involving human beings is conditioned to the fulfillment of the ethical principles contained in the Declaration of Helsinki (2008) from the World Medical Association. Compliance with the specific legislation of the country in which the research was carried out must be observed.

Research ethics, informed consent and patient details

Studies with patients or volunteers require informed consent and approval from a Research Ethics Review Committee (ERC). The protocol number issued by the ERC must be informed in the body of the article under review, specifically, in the last paragraph of the Methods section. One copy of the approval granted by the ERC must be attached and sent through the OJS electronic system. Authors must obtain the appropriate consents, permissions and releases related with the details and information of a patient's case or images of patients, and of any other individuals contained in the submission file. Written consents must be retained by the author but must not be sent to the journal. If it is necessary to show the patient's face or if the patient can be recognized from the image, then the authors must send a document of proper consent obtained from the patient when submitting the article, informing that the image will be used exclusively for scientific purposes. Authors should provide copies of consents or evidence that such consents were obtained only if requested in exceptional circumstances (e.g. if any legal issue arises). Even if the authors have a written permission from the patient or close relatives, any patient's personal information may not be included in any part of the article or supplemental material (including all illustrations and videos).

It is the responsibility of the authors to ensure that:

The written consent form meets every requirement of all applicable data protection and privacy laws. Particular care should be taken in obtaining consent with respect to children (in particular when a child has special needs or learning disabilities), when an individual's head or face is shown, or when reference is made to a participant's name or other personal details.

Concerning studies involving children, if the parent or guardian disagrees about the use of a child's image, then this image must not be used. It is also important to ensure that only images of children in appropriate attire are used in order to reduce the risk of them being used inappropriately.

Even if consent has been obtained, attention must be taken to ensure that the individual's portrait and caption are presented in a respectful manner and that they do not adversely affect that individual.

Studies in humans and animals

Research involving experiments on human beings must follow the World Medical Association's Ethical Principles (Declaration of Helsinki). The manuscript must also conform to the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals (ICMJE) and include representative human populations (gender, age, and ethnicity) in accordance with these recommendations. The terms sex and gender must be used correctly.

The authors must include a statement in the manuscript that informed consent was obtained in experiments involving human subjects. Research subjects' privacy rights must always be observed.

All animal experiments must comply with the ARRIVE guidelines and be conducted in accordance with the U.K. Animals (Scientific Procedures) Act 1986 and associated guidelines, the EU Directive 2010/63/EU on the protection of animals used for scientific experiments, the National Institutes of Health guidelines for the care and use of laboratory animals (NIH Publication No. 8023, revised in 1978), and other national guidelines and legislation. Authors must clearly state in the manuscript that these guidelines were followed. The sex of animals must be indicated, and where appropriate, the influence (or association) of sex on the results of the study.