Diabetes mellitus e gravidade por COVID-19 em brasileiros hospitalizados

Thiago Santos Garces; George Jó Bezerra Sousa; Virna Ribeiro Feitosa Cestari; Samuel Miranda Mattos; Raquel Sampaio Florêncio; Maria Lúcia Duarte Pereira; Thereza Maria Magalhães Moreira

doi:10.15253/2175-6783.20222381354

Autores/as

Thiago Santos Garces Universidade Estadual do Ceará https://orcid.org/0000-0002-1670-725X
George Jó Bezerra Sousa Universidade Estadual do Ceará https://orcid.org/0000-0003-0291-6613
Virna Ribeiro Feitosa Cestari Universidade Estadual do Ceará https://orcid.org/0000-0002-7955-0894
Samuel Miranda Mattos Universidade Estadual do Ceará https://orcid.org/0000-0002-1837-9480
Raquel Sampaio Florêncio Universidade Estadual do Ceará https://orcid.org/0000-0003-3119-7187
Maria Lúcia Duarte Pereira Universidade Estadual do Ceará https://orcid.org/0000-0003-0079-5248
Thereza Maria Magalhães Moreira Universidade Estadual do Ceará https://orcid.org/0000-0003-1424-0649

DOI:

https://doi.org/10.15253/2175-6783.20222381354

Palabras clave:

Diabetes Mellitus; Infecções por Coronavírus; Hospitalização; Índice de Gravidade de Doença; Estudos Transversais.

Resumen

Objetivo: estimar a prevalência de gravidade de casos hospitalizados de COVID-19 e sua associação com o diabetes mellitus. Métodos: estudo transversal, que utilizou base de dados secundários do Sistema de Informação de Vigilância Epidemiológica da Gripe, totalizando 405.294 casos confirmados. Para verificar a associação do diabetes e a gravidade em pacientes com COVID-19 hospitalizados, foram usados modelos de regressão de Poisson com estimador de variância robusta. Inicialmente, verificou-se a associação da doença com o desfecho; em seguida, foram realizados diversos ajustes para os potenciais confundidores. Resultados: a prevalência de diabetes nos 405.294 casos hospitalizados e positivos foi de 25,7% (Intervalo de Confiança: 25,5% - 25,8%). Após ajustes, observou-se que a diabetes aumentou a gravidade da COVID-19 em 19% (Intervalo de Confiança: 1,17 – 2,21). Conclusão: identificou-se associação importante do diabetes mellitus com casos graves de infecção pela COVID-19. Contribuições para a prática: a evidência gerada pelo estudo guia a estratificação de risco de pacientes e direciona o manejo clínico.

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